GenTooControl PROJECT

FRRB Project 1751658 - Leveraging gene-based tools to control local and systemic circuits of tumor tolerance


Name and Surname of PI

Mario Leonardo Squadrito

Project Acronym


Project ID


Host Institution

IRCCS Ospedale San Raffaele - Milan

Pathology of Interest

Tumor Microenvironment

Research Area


Project Start Date

1 June 2021

Project End Date

31 May 2024


€ 599.840,00

Type of Project



Liver metastases are associated with a poor prognosis and current drug therapies are ineffective in most cases. Cancer cells within liver metastases contain antigens which have the potential to trigger the activation of the immune system. However, immunosuppressive circuits in the tumor microenvironment inhibit immune responses, thus promoting tumor growth and progression. The aim of this project is to identify new mechanisms of inhibition of the immune system in tumors and to use innovative gene transfer strategies to develop a vaccine against cancer cells whose action is not inhibited by the tolerogenic mechanisms of tumors.