FRRB Project 1750818 - Decoding the molecular basis of the interplay between neuroinflammation and neurodegeneration in Parkinson’s disease
|
Name and Surname of PI |
Simone Bido |
|
Project Acronym |
InflammaPark |
|
Project ID |
1750818 |
|
Host Institution |
IRCCS Ospedale San Raffaele - Milan |
|
Pathology of Interest |
Parkinson's Disease |
|
Research Area |
Neurology |
|
Project Start Date |
1 May 2021 |
|
Project End Date |
30 April 2024 |
|
Funding |
€ 575.420,00 |
|
Type of Project |
Individual |
PROJECT SUMMARY
Parkinson’s disease affects about the 1% of the population over 60 worldwide, with no negligible cases in the group of population of 30-60 years old. Like in other diseases, inflammation seems to have a crucial role in Parkinson’s disease development. The objective of this project is to describe the molecular mechanisms by which the inflammatory process is able to elicit and sustain the degeneration of the dopaminergic neurons (the most affected in Parkinson’s disease). To achieve this result, we will take advantage from advanced technics of molecular investigation, which enable the detailed analysis of the data collected from ad hoc animal models and human biological samples from parkinsonian patients. These findings will allow us to devise pharmacological and genetic treatments suitable to mitigate and block the disease progression together with the identification of possible molecular markers for an early-stage diagnosis.