FRRB Project 1750327 - Personalized brain organoid model of premature aging in multiple sclerosis
|
Name and Surname of PI |
Martina Absinta |
|
Project Acronym |
MODEL-MS-AGING |
|
Project ID |
1750327 |
|
Host Institution |
IRCCS Ospedale San Raffaele - Milan |
|
Pathology of Interest |
Multiple Sclerosis |
|
Research Area |
Autoimmune Diseases |
|
Project Start Date |
14 June 2021 |
|
Project End Date |
13 June 2024 |
|
Funding |
€ 531.320,00 |
|
Type of Project |
Individual |
PROJECT SUMMARY
Multiple sclerosis (MS) is a disease of the central nervous system in which inflammation and neurodegeneration coexist. Although there are very effective therapies, some people with MS can accumulate disability over time, generally after the age of 45. Mechanisms leading to neurodegeneration and their relationship with aging are not clear yet. My working hypothesis is that chronic brain inflammation contributes to premature brain aging. The main objective of this research project is therefore to investigate the role of cellular senescence by studying the MS brain tissue at very high resolution with a technique called "spatial transcriptomics", and to create a customized 3D cellular model derived from patients with or without chronic active lesions seen on 3-tesla MRI. These 3D cellular models could be used in the future to test treatments halting neurodegeneration.
On September 8, 2022 the principal investigator recorded an audio podcast entitled “triMS Audio Podcast: Smouldering MS: What is it and how to approach it”, available at the following link: https://www.trimsonlineconference.com/trimsaudio-overview/trimsaudio-episode-4
On June 26, 2023 the principal investigator recorded a video within NeurologyTalk format entitled “Aging with Multiple Sclerosis”, available at the following link: https://neurologytalk.healthtalks.it