PROGETTO CANLAB

Progetto FRRB ID 4986890 - Conformational Antibodies and Neuromuscular disorders and: LABoratory diagnostic and novel targets (CANLAB)

Dati del progetto

Principal Investigator

 Dr. Matteo Gastaldi

Ente ospitante

Fondazione Istituto Neurologico Nazionale Casimiro Mondino

Area Tematica

Neurologia

Data di inizio Progetto

16/12/2024

Data di fine Progetto

15/12/2027

Importo assegnato

411.342,08 €

Tipo Progetto

Individuale

PROJECT AIMS

Neuromuscular disorders (NMD) associated with conformational antibodies (abs) include several conditions such as Guillain-Barrè Syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) with paranodal/nodal proteins abs (PNAbs) and myasthenia gravis (MG). PNAbs detection orients treatment, but laboratory assays are not standardized, and novel abs targets await to be discovered. Moreover, abs effector functions have not been thoroughly investigated. In this study we aim to:

• Define the best laboratory strategy for PNAbs;

• Characterize novel abs targets in neuromuscolar disorsers;

• Characterize abs effector functions in neuromuscolar disorsers.