PROGETTO GEAM

Progetto FRRB ID 4977360 - Yield of GEnetic testing in Arrhythmic Myocarditis (GEAM)

Dati del progetto

Principal Investigator

Dr. Giovanni Peretto

Ente ospitante

IRCCS Ospedale San Raffaele

Area Tematica

Cardiologia

Data di inizio Progetto

02/12/2024

Data di fine Progetto

01/12/2027

Importo assegnato

 499.999,20 €

Tipo Progetto

Individuale

PROJECT AIMS 

Arrhythmic myocarditis is responsible for out-of-hospital cardiac arrest in many young people. Although the molecular mechanisms of the disease are unknown, recent reports suggest that pathogenic cardiomyopathic gene variants (CGVs) are frequently found in patients with myocarditis complicated by ventricular arrhythmias (VA). However, the issue lacks systematic and sex-specific investigation. This research project aims at:

      • Defining the prevalence of CGVs in females and males with arrhythmic myocarditis;
      • Describing the prognostic value of CGVs;
      • Identifying gene expression profiles associated with VA in cardiac tissue.