PROGETTO MITOGEN-GBA

Progetto FRRB ID 4986772- Effect of sex and GBA interaction on oxidative stress in shaping pd pathology: a multimodal study (MITOGEN-GBA)

Dati del progetto

Principal Investigator

Dr.ssa Micol Avenali

Ente ospitante

Fondazione Istituto Neurologico Nazionale Casimiro Mondino

Area Tematica

Neurologia

Data di inizio Progetto

13/01/2025

Data di fine Progetto

12/01/2028

Importo assegnato

 499.996,40 €

Tipo Progetto

Individuale

PROJECT AIM

Protein aggregation, mitochondrial damage and oxidative stress play a central role in Parkinson’s disease pathogenesis, and this is known to be influenced by genetic mutations as well as by sex hormones. Heterozygous mutations in the GBA gene are the strongest genetic factor increasing Parkinson’s disease risk and are associated with a more severe phenotype. The project aims to investigate how sex hormone levels interact with GBA gene mutations to impact on mitochondrial/redox homeostasis, lipid balance and neurodegeneration in Parkinson’s disease.