Progetto FRRB ID 4986772- Effect of sex and GBA interaction on oxidative stress in shaping pd pathology: a multimodal study (MITOGEN-GBA)
Dati del progetto
Principal Investigator |
Dr.ssa Micol Avenali |
Ente ospitante |
Fondazione Istituto Neurologico Nazionale Casimiro Mondino |
Area Tematica |
Neurologia |
Data di inizio Progetto |
13/01/2025 |
Data di fine Progetto |
12/01/2028 |
Importo assegnato |
499.996,40 € |
Tipo Progetto |
Individuale |
PROJECT AIM
Protein aggregation, mitochondrial damage and oxidative stress play a central role in Parkinson’s disease pathogenesis, and this is known to be influenced by genetic mutations as well as by sex hormones. Heterozygous mutations in the GBA gene are the strongest genetic factor increasing Parkinson’s disease risk and are associated with a more severe phenotype. The project aims to investigate how sex hormone levels interact with GBA gene mutations to impact on mitochondrial/redox homeostasis, lipid balance and neurodegeneration in Parkinson’s disease.