PROGETTO SPRINT-PD

Progetto FRRB ID 4981375 - Somatic recombination and inflammatory signatures for Parkinson's disease diagnosis and treatment (SPRINT-PD)

Dati del progetto

Principal Investigator

Dr.ssa Letizia Straniero

Ente ospitante

IRCCS Istituto Clinico Humanitas

Area Tematica

Neurologia

Data di inizio Progetto

01/12/2024

Data di fine Progetto

30/11/2027

Importo assegnato

500.000,00 €

Tipo Progetto

Individuale

PROJECT AIM

Parkinson's disease etiology is complex and involve different and largely unknown environmental factors and genetics determinates. This challenges early diagnosis that, despite proposed biomarkers, remains elusive. Somatic non-allelic homologous recombination (NAHR), disrupting genetic information or affecting regulatory regions, could contribute to aging and neurodegenerative disorders. This study aims to develop Parkinson's disease non-invasive diagnostic tools understanding how a chronic disorder affects genomic stability in immune cells. It also explores the inflammation role in Parkinson's disease, thus potentially leading to novel therapeutic strategies.